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Analysis of institutional authors

Basora Gallisa, JosepAuthorMartín Lujan, Francisco ManuelAuthorSalas-Salvado, JAuthor

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Article

Inverse association between habitual polyphenol intake and incidence of cardiovascular events in the PREDIMED study

Publicated to:Nutrition Metabolism And Cardiovascular Diseases. 24 (6): 639-647 - 2014-06-01 24(6), DOI: 10.1016/j.numecd.2013.12.014

Authors: Tresserra-Rimbau, A; Rimm, E B; Medina-Remon, A; Martinez-Gonzalez, M A; de la Torre, R; Corella, D; Salas-Salvado, J; Gomez-Gracia, E; Lapetra, J; Aros, F; Fiol, M; Ros, E; Serra-Majem, L; Pinto, X; Saez, G T; Basora, J; Sorli, J V; Martinez, J A; Vinyoles, E; Ruiz-Gutierrez, V; Estruch, R; Lamuela-Raventos, R M

Affiliations

Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA      Harvard University - Author
CSIC, Inst Grasa, E-41080 Seville, Spain      CSIC - Instituto de la Grasa (IG)    Consejo Superior de Investigaciones Cientificas (CSIC) - Author
Harvard Univ, Sch Med, Boston, MA USA      Harvard University - Author
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA      Harvard University - Author
Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA      Harvard University - Author
Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAP, Lipid Clin, Barcelona, Spain      University of Barcelona    Hospital Clinic de Barcelona    IDIBAPS - Author
Hosp Clin Barcelona, UB, IDIBAPS, Dept Internal Med, Barcelona, Spain      University of Barcelona    IDIBAPS    Hospital Clinic de Barcelona - Author
Hosp Univ Bellvitge, FIPEC, IDIBELL, Dept Internal Med,Lipid Unit, Barcelona, Spain      Bellvitge University Hospital    Institut d'Investigacio Biomedica de Bellvitge (IDIBELL)    Catalan Health Institute    University of Barcelona - Author
Inst Invest Atenc Primaria Jordi Gol, Catalan Inst Hlth, Primary Care Div, Reus, Spain      Catalan Health Institute       - Author
Inst Univ Invest Ciencies Salut, Palma de Mallorca, Spain - Author
Municipal Inst Med Res, Cardiovasc Epidemiol Unit, Barcelona, Spain - Author
San Pablo Hlth Ctr, Primary Care Div Sevilla, Dept Family Med, Seville, Spain       - Author
UB, La Mina Primary Care Ctr, Barcelona, Spain      University of Barcelona - Author
Univ Barcelona, INSA, XaRTA, Sch Pharm,Nutr & Food Sci Dept, Av Joan XXIII S-N, E-08028 Barcelona, Spain.      University of Barcelona - Author
Univ Barcelona, INSA, XaRTA, Sch Pharm,Nutr & Food Sci Dept, E-08028 Barcelona, Spain      University of Barcelona - Author
Univ Hosp Alava, Dept Cardiol, Vitoria, Spain       - Author
Univ Las Palmas Gran Canaria, Dept Clin Sci, Palmas De Gran Canaria, Spain      Universidad de Las Palmas de Gran Canaria - Author
Univ Malaga, Sch Med, Dept Epidemiol, Malaga, Spain      Universidad de Malaga       - Author
Univ Navarra, Dept Nutr & Food Sci, E-31080 Pamplona, Spain      University of Navarra - Author
Univ Navarra, Sch Med, Dept Prevent Med & Publ Hlth, E-31080 Pamplona, Spain      University of Navarra       - Author
Univ Rovira & Virgili, IISPV, Sch Med, Human Nutr Unit, E-43201 Reus, Spain      Institut d'Investigacio Sanitaria Pere Virgili (IISPV)    Universitat Rovira i Virgili - Author
Univ Valencia, Sch Med, Dept Biochem, Valencia, Spain      University of Valencia - Author
Univ Valencia, Sch Med, Dept Epidemiol Prevent Med & Publ Hlth, Valencia, Spain      University of Valencia - Author
Valencian Inst Hlth, Valencia, Spain - Author
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Abstract

Epidemiologic and biological evidence supports an inverse association between polyphenol consumption and the risk of cardiovascular disease (CVD). However, no previous studies have prospectively evaluated the relationship between polyphenol intake and the incidence of CVD in such a comprehensive way. The aim was to evaluate the association between intakes of total polyphenol and polyphenol subgroups, and the risk of major cardiovascular events (myocardial infarction, stroke or death from cardiovascular causes) in the PREDIMED study.The present work is an observational study within the PREDIMED trial. Over an average of 4.3 years of follow-up, there were 273 confirmed cases of CVD among the 7172 participants (96.3%) who completed a validated 137-item food frequency questionnaire (FFQ) at baseline. Polyphenol consumption was calculated by matching food consumption data from the FFQ with the Phenol-Explorer database on polyphenol content of each reported food. After multivariate adjustment, a 46% reduction in risk of CVD risk was observed comparing Q5 vs. Q1 of total polyphenol intake (HR = 0.54; 95% confidence interval [CI] = 0.33-0.91; P-trend = 0.04). The polyphenols with the strongest inverse associations were flavanols (HR = 0.40; CI 0.23-0.72; P-trend = 0.003), lignans (HR = 0.51; CI 0.30-0.86; P-trend = 0.007), and hydroxybenzoic acids (HR = 0.47; CI 0.26-0.86; P-trend 0.02).Greater intake of polyphenols, especially from lignans, flavanols, and hydroxybenzoic acids, was associated with decreased CVD risk. Clinical trials are needed to confirm this effect and establish accurate dietary recommendations.Copyright © 2014 Elsevier B.V. All rights reserved.

Keywords

cardiovascular diseasesdietepidemiologyCardiovascular diseasesDietEpidemiologyPolyphenols

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Nutrition Metabolism And Cardiovascular Diseases due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2014, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine (Miscellaneous). Notably, the journal is positioned above the 90th percentile.

This publication has been distinguished as a “Highly Cited Paper” by the agencies WoS (ESI, Clarivate) and ESI (Clarivate), meaning that it ranks within the top 1% of the most cited articles in its thematic field during the year of its publication. In terms of the observed impact of the contribution, this work is considered one of the most influential worldwide, as it is recognized as highly cited. (source consulted: ESI Nov 14, 2024)

And this is evidenced by the extremely high normalized impacts through some of the main indicators of this type, which, although dynamic over time and dependent on the set of average global citations at the time of calculation, already indicate that they are well above the average in different agencies:

  • Normalization of citations relative to the expected citation rate (ESI) by the Clarivate agency: 7.14 (source consulted: ESI Nov 14, 2024)
  • Weighted Average of Normalized Impact by the Scopus agency: 9.07 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 45.09 (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-19, the following number of citations:

  • WoS: 259
  • Scopus: 292
  • Europe PMC: 133
  • Google Scholar: 236
  • OpenCitations: 273

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-19:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 390.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 390 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 54.85.
  • The number of mentions on the social network X (formerly Twitter): 6 (Altmetric).
  • The number of mentions in news outlets: 6 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States of America.