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Analysis of institutional authors

Yebras CaÑellas, MartínAuthorCatalán Santos, úrsulaAuthorFernández Castillejo, SaraAuthorFernández-Castillejo SAuthorSolà Alberich, Rosa MariaAuthor

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Inhibition of the transcription factor c-Jun by the MAPK family, and not the NF-κB pathway, suggests that peanut extract has anti-inflammatory properties

Publicated to:Molecular Immunology. 52 (3-4): 125-132 - 2012-10-01 52(3-4), DOI: 10.1016/j.molimm.2012.05.007

Authors: Catalan, Ursula; Fernandez-Castillejo, Sara; Angles, Neus; Ramon Morello, Jose; Yebras, Marti; Sola, Rosa

Affiliations

La Morella Nuts SA, Tarragona 43206, Spain - Author
LA MORELLA NUTS, S.A. - Author
Univ Rovira & Virgili, Fac Med & Ciencies Salut, Hosp Univ St Joan, Unitat Recerca Lipids & Arteriosclerosi,IISPV,CIB, Tarragona 43201, Spain - Author
Univ Rovira & Virgili, Serv Cient & Tecn, Tarragona 43201, Spain - Author
Universitat Rovira i Virgili - Author
University Hospital Sant Joan de Reus - Author
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Abstract

Background: Tumor necrosis factor-α (TNF-α) is involved in inflammatory responses in atherosclerosis. We propose an in vitro cellular assay to evaluate the anti-inflammatory mechanisms of potential modifiers such as food extracts. In the current model we assessed an anti-inflammatory effect of polyphenol-rich peanut extract in lipopolysaccharide (LPS)-induced THP-1 monocytes. Methods: THP-1 monocytes were incubated with peanut extract (5, 25, 50 and 100 μg/mL) consisting of 39% flavonols, 37% flavanols and 24% phenolic acid (or BAY 11-7082 (5 μM) as experiment control) for 1. h and then stimulated with LPS (500. ng/mL) for 4. h. Cytotoxicity was measured as lactate dehydrogenase (LDH) activity release. NF-κB and MAPK family were determined by TransAm kit while TNF-α mRNA levels and its mRNA stability by RT-PCR. Intra- and extracellular TNF-α protein was measured by ELISA, and TNF-α converting enzyme (TACE) activity by a fluorimetric assay. Results: Peanut extract inhibited the maximal LPS-induced extracellular TNF-α protein secretion by 18%, 29% and 47% at 25, 50 and 100 μg/mL, respectively (P< 0.05). LPS stimulation revealed that 85% of TNF-α was released extracellularly while 15% remained intracellular. Peanut extract did not modify NF-κB but, instead, reduced c-Jun transcription factor activity (P< 0.05), decreased TNF-α mRNA (albeit non-significantly) and had no effect on mRNA stability and TACE activity. Conclusion: Polyphenol-rich peanut extract reduces extracellular TNF-α protein by inhibiting c-Jun transcription factor from MAPK family, suggesting an anti-inflammatory effect. The proposed THP-1 monocyte model could be used to assess food extract impact (site and size effects) on the inflammation pathway. © 2012 Elsevier Ltd.

Keywords

Adam proteinsAdam17 proteinAdam17 protein, humanAnti-inflammatory agents, non-steroidalArachisCell lineCell line, tumorHumansJnk mitogen-activated protein kinasesL-lactate dehydrogenaseLipopolysaccharideLipopolysaccharidesMonocytesNf-?bNf-kappa bNf-kbNf-κbPlant extractsSignal transductionTaceThp-1Tnf-alphaTumor necrosis factor-?Tumor necrosis factor-? converting enzymeTumor necrosis factor-alphaTumor necrosis factor-αTumor necrosis factor-α converting enzyme

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Molecular Immunology due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2012, it was in position , thus managing to position itself as a Q2 (Segundo Cuartil), in the category Immunology. Notably, the journal is positioned en el Cuartil Q3 for the agency WoS (JCR) in the category Biochemistry & Molecular Biology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-06-25:

  • Google Scholar: 14
  • WoS: 10
  • Scopus: 10
  • Europe PMC: 6
  • OpenCitations: 11

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-25:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 21.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 21 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.5.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Catalán Ú) and Last Author (Sola R).