{rfName}

Indexed in

License and use

Icono OpenAccess

Citations

19

Altmetrics

Grant support

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This work was partially supported by grants from: LB: Agencia de Gestio d'Ajuts Universitaris i de Recerca of the Government of Catalonia (Grant number 2017 SGR 1718). RI: AEPCC investiga 2016 - Xavier Castellsague Grant. Finally this study has been funded by Instituto de Salud Carlos III through the project PI16/01254 and CIBERESP CB06/02/0073 (co-funded by FEDER funds/European Regional Development Fund (ERDF), a way to build Europe) and RecerCaixa 2015 (MD088652). We also thank CERCA Programme/Generalitat de Catalunya for institutional support. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Analysis of institutional authors

Fibla MAuthorGutierrez CAuthor

Share

September 6, 2020
Publications
>
Article
Sí

Long-term protection of HPV test in women at risk of cervical cancer

Publicated to:Plos One. 15 (8): e0237988-e0237988 - 2020-08-27 15(8), DOI: 10.1371/journal.pone.0237988

Authors: Ibanez, Raquel; Roura, Esther; Monfil, Laura; Alejandro Rodriguez, Luis; Sarda, Montserrat; Crespo, Nayade; Pascual, Amparo; Marti, Clara; Fibla, Montserrat; Gutierrez, Cristina; Lloveras, Belen; Oliveres, Gloria; Torrent, Anna; Catala, Isabel; Xavier Bosch, Francesc; Bruni, Laia; de Sanjose, Silvia

Affiliations

Catalan Inst Oncol ICO, Canc Epidemiol Res Programme, DIBELL, Barcelona, Spain - Author
Catalan Inst Oncol ICO, Unit Infect & Canc Informat & Intervent, DIBELL, Barcelona, Spain - Author
Consorci Hosp Vic, Pathol Dept, Barcelona, Spain - Author
Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain - Author
Hosp del Mar, Pathol Dept, Barcelona, Spain - Author
Hosp Gen Granollers, Pathol Dept, Barcelona, Spain - Author
Hosp Univ Bellvitge, Pathol Dept, IDIBELL, Catalan Inst Oncol, Barcelona, Spain - Author
Hosp Univ Dr Josep Trueta Girona, Pathol Dept, Catalan Inst Oncol, Girona, Spain - Author
Hosp Univ Joan XXIII Tarragona, Pathol Dept, Tarragona, Spain - Author
IISPV Rovira & Virgili Univ, Clin Lab ICS Tarragona, Mol Biol Sect, Hosp Univ Joan XXIII Tarragona, Tarragona, Spain - Author
Inst Catala Salut Mollet Valles, Sexual & Reprod Hlth Ctr Mollet Valles, Barcelona, Spain - Author
Inst Catala Salut, Sexual & Reprod Hlth Ctr Bages Solsones, Barcelona, Spain - Author
PATH, Seattle, WA USA - Author
Pompeu Fabra Univ, Publ Hlth Master, Barcelona, Spain - Author
See more

Abstract

To evaluate the 9-year incidence of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and cumulative adherence to perform a next test in a cohort of women aged 40+ years with no cervical screening cytology within a window of 5 years (underscreened women), after baseline cervical cytology and HPV tests.In Catalonia, Spain, co-testing with cytology and HPV test has been recommended in the Public Health system since 2006 for underscreened women. In 2007, 1,594 women with underscreened criteria were identified and followed through medical records form Pathological Department. 9-year cumulative incidence of histologically confirmed CIN2+ and cumulative adherence to perform a next test were estimated using Kaplan-Meier statistics.Follow-up was available for 1,009 women (63.3%) resulting in 23 women with. CIN2+ (2.3%). Of them, 4 women (17%) had both tests negative at baseline (3CIN2 and 1CIN3) with cumulative incidence of CIN2+ of 0.4% (95% CI: 0.1-1.4) at 5-years and 1.3% (95% CI: 0.4-3.7) at 9-years. During the first year, the prevalence among women with both tests positive was 27.0% (95% CI: 13.0-50.6) for CIN2+. Lost to follow-up was higher among women with both tests negative compared to those with both positive tests (38.7% vs 4.2%, p-value <0.001). 40.5% of the women HPV-/cyto- had a re-screening test during the 4 years following the baseline, increasing until 53.5% during the 6 years of follow-up.HPV detection shows a high longitudinal predictive value at 9-year to identify women at risk to develop CIN2+. The data validate a safe extension of the 3-year screening intervals (current screening interval) to 5-year intervals in underscreened women that had negative HPV result at baseline. It is necessary to establish mechanisms to ensure screening participation and adequate follow-up for these women.

Keywords

AgedCohort studiesCytologyDesignEarly detection of cancerEnglandFemaleFollow-up studiesGuidelinesHuman-papillomavirusHumansMass screeningMiddle agedNonparticipationPapillomaviridaeRandomized controlled-trialRiskTime factorsUterine cervical neoplasms

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Plos One due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Multidisciplinary. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.2, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-16, the following number of citations:

  • WoS: 6
  • Scopus: 8
  • Europe PMC: 5

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 32.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 36 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 5.75.
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/20.500.11797/imarina8052376

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States of America.