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Analysis of institutional authors

Muralidharan, JAuthorBullo, MCorresponding AuthorAtzeni, AAuthorGomez-Perez, AmAuthorGalie, SAuthorSalas-Salvado, JAuthor
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Effect on gut microbiota of a 1-y lifestyle intervention with Mediterranean diet compared with energy-reduced Mediterranean diet and physical activity promotion: PREDIMED-Plus Study

Publicated to:American Journal Of Clinical Nutrition. 114 (3): 1148-1158 - 2021-09-01 114(3), DOI: 10.1093/ajcn/nqab150

Authors: Muralidharan, Jananee; Moreno-Indias, Isabel; Bullo, Monica; Vioque Lopez, Jesus; Corella, Dolores; Castaner, Olga; Vidal, Josep; Atzeni, Alessandro; Carlos Fernandez-Garcia, Jose; Torres-Collado, Laura; Fernandez-Carrion, Rebeca; Fito, Monsterrat; Olbeyra, Romina; Maria Gomez-Perez, Ana; Galie, Serena; Rosa Bernal-Lopez, Maria; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Jose Tinahones, Francisco

Affiliations

August Pi I Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain - Author
Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA - Author
Hosp Clin Univ, Endocrinol & Nutr Dept, Barcelona, Spain - Author
Hosp del Mar Res Inst IMIM, Cardiovasc Risk & Nutr Regicor Study Grp, Barcelona, Spain - Author
Hosp Reg Univ Malaga, UGC Med Interna, Malaga, Spain - Author
Inst Salud Carlos III ISCIII, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain - Author
Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain - Author
ISABIAL UMH, Inst Invest Sanitaria & Biomed Alicante, Alicante, Spain - Author
Univ Malaga, Hosp Univ Malaga Virgen de laVictoria, Lab Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Malaga, Spain - Author
Univ Navarra, Dept Prevent Med & Publ Hlth, IdisNA, Pamplona, Spain - Author
Univ Rovira & Virgili, Inst Invest Sanitaries Pere & Virgili, Dept Biochem & Biotechnol, Human Nutr Unit,Hosp Univ St Joan de Reus, Reus, Spain - Author
Univ Valencia, Dept Prevent Med, Valencia, Spain - Author
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Abstract

Background: The Mediterranean diet is a well-recognized healthy diet that has shown to induce positive changes in gut microbiota. Lifestyle changes such as diet along with physical activity could aid in weight loss and improve cardiovascular risk factors.Objectives: To investigate the effect of an intensive lifestyle weight loss intervention on gut microbiota.Methods: This is a substudy of the PREDIMED-Plus (Prevention con Dieta Mediterrdnea-Plus), a randomized controlled trial conducted in overweight/obese men and women (aged 55-75 y) with metabolic syndrome. The intervention group (IG) underwent an intensive weight loss lifestyle intervention based on an energy-restricted Mediterranean diet (MedDiet) and physical activity promotion. and the control group ((Xi) underwent a non-energy-restricted MedDiet for 1 y. Anthropometric, biochemical, and gut microbial 16S rRNA sequencing data were analyzed at baseline (n = 362) and 1-y follow-up (n = 343).Results: IG participants had a weight loss of 4.2 (IQR, -6.8, -2.5) kg compared with 0.2 (IQR, -2.1. 1.4) kg in the CG (P < 0.001). Reductions in BMI, fasting glucose, glycated hemoglobin, and triglycerides and an increase in HDL cholesterol were greater in IG than inCG participants (P < 0.05). We observed a decrease in Butyricicoccus, Haentophilus. Ruminiclostridium 5, and Eubacterium hall in the IG compared with the CG. Many genera shifted in the same direction within both intervention groups, indicating an overall effect of the MedDiet. Decreases in Themophilus. Coprococcus 3, and few other genera were associated with a decrease in adiposity parameters in both intervention groups. Changes in Lachnospiraceae NK4A136 were positively associated with changes in MedDiet adherence.Conclusions: Weight loss induced by an energy-restricted MedDiet and physical activity induce changes in gut microbiota. The role of MedDiet-induced changes on the host might be via short-chain fatty acid producing bacteria, whereas with energy restriction, these changes might be modulated with other mechanisms, which need to be explored in future studies.

Keywords
AgedBacteriaBacterial rnaBacteriumCaloric intakeCaloric restrictionClassificationControlled studyDiet, mediterraneanEnergy intakeEnergy restrictionExerciseFecesFemaleGastrointestinal microbiomeGeneticsGut microbiotaHumanHumansIntestine floraLife styleLifestyleMaleMediterranean dietMenMetabolic syndromeMetabolic syndrome xMicrobiologyMiddle agedObesityOverweightPhylogenyRandomized controlled trialRna 16sRna, bacterialRna, ribosomal, 16sWeight loss

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal American Journal Of Clinical Nutrition due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 8/90, thus managing to position itself as a Q1 (Primer Cuartil), in the category Nutrition & Dietetics. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 4.42. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 6.32 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 22.29 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-13, the following number of citations:

  • WoS: 77
  • Scopus: 84
  • Europe PMC: 50
  • Google Scholar: 90
  • OpenCitations: 72
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-13:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 401.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 396 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 192.3.
  • The number of mentions on the social network X (formerly Twitter): 26 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/20.500.11797/imarina9230374
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Muralidharan, Jananee) .

the author responsible for correspondence tasks has been Bulló Bonet, Mònica.