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Grant support

Z.W., H.V., and L.L. acknowledge an Australian Commonwealth Government Research Training Program Tuition Fee Offset and Z.W. and H.V. acknowledge an Australian Commonwealth Government Research Stipend Scholarship. A.S.W. acknowledges funding from the National Health and Medical Research Council. A.S.W. thanks Dr. Yadong Wang for encouraging the use of PGS. The authors acknowledge the technical and scientific assistance of Sydney Microscopy & Microanalysis, the University of Sydney node of Microscopy Australia and Sydney Analytical, a core research facility at The University of Sydney. All animal experiments and procedures were approved by Sydney Local Health District Animal Welfare Committee (AWC No. 2013/019D) under the Australian National Health and Medical Research Council guidelines for animal experimentation.

Analysis of institutional authors

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Article

Rapid Regeneration of a Neoartery with Elastic Lamellae

Publicated to:Advanced Materials. 34 (47): - 2022-11-24 34(47), DOI: 10.1002/adma.202205614

Authors: Wang Z; Mithieux SM; Vindin H; Wang Y; Zhang M; Liu L; Zbinden J; Blum KM; Yi T; Matsuzaki Y; Oveissi F; Akdemir R; Lockley KM; Zhang L; Ma K; Guan J; Waterhouse A; Pham NTH; Hawkett BS; Shinoka T; Breuer CK; Weiss AS

Affiliations

Anzac Res Inst, Burns Res & Reconstruct Surg, Sydney, NSW 2139, Australia - Author
Beihang Univ, Int Res Ctr Adv Struct & Biomat, Sch Mat Sci & Engn, Beijing 100191, Peoples R China - Author
Nanjing Univ Chinese Med, Jiangsu Prov Engn Res Ctr TCM External Medicat De, Nanjing 210023, Jiangsu, Peoples R China - Author
Nationwide Childrens Hosp, Ctr Regenerat Med, Abigail Wexner Res Inst, Columbus, OH 43215 USA - Author
Univ Rovira & Virgili, Dept Chem Engn, E-43007 Tarragona, Spain - Author
Univ Sydney, Charles Perkins Ctr, Sydney, NSW 2006, Australia - Author
Univ Sydney, Fac Med & Hlth, Sch Med Sci, Sydney, NSW 2006, Australia - Author
Univ Sydney, Heart Res Inst, Sydney, NSW 204206, Australia - Author
Univ Sydney, Key Ctr Polymers & Colloids, Sch Chem, Sydney, NSW 2006, Australia - Author
Univ Sydney, Nano Inst, Sydney, NSW 2006, Australia - Author
Univ Sydney, Sch Chem & Biomol Engn, Sydney, NSW 2006, Australia - Author
Univ Sydney, Sch Life & Environm Sci, Sydney, NSW 2006, Australia - Author
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Abstract

Native arteries contain a distinctive intima-media composed of organized elastin and an adventitia containing mature collagen fibrils. In contrast, implanted biodegradable small-diameter vascular grafts do not present spatially regenerated, organized elastin. The elastin-containing structures within the intima-media region encompass the elastic lamellae (EL) and internal elastic lamina (IEL) and are crucial for normal arterial function. Here, the development of a novel electrospun small-diameter vascular graft that facilitates de novo formation of a structurally appropriate elastin-containing intima-media region following implantation is described. The graft comprises a non-porous microstructure characterized by tropoelastin fibers that are embedded in a PGS matrix. After implantation in mouse abdominal aorta, the graft develops distinct cell and extracellular matrix profiles that approximate the native adventitia and intima-media by 8 weeks. Within the newly formed intima-media region there are circumferentially aligned smooth muscle cell layers that alternate with multiple EL similar to that found in the arterial wall. By 8 months, the developed adventitia region contains mature collagen fibrils and the neoartery presents a distinct IEL with thickness comparable to that in mouse abdominal aorta. It is proposed that this new class of material can generate the critically required, organized elastin needed for arterial regeneration.

Keywords
Blood-pressureCollagenElastic lamellaeElastinEndotheliumExpressionHaploinsufficiencyHypertensionInternal elastic laminaNitric-oxide synthasePolyglycerol sebacateRegenerative medicineShear-stressTissue engineeringTropoelastinVascular grafts

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Advanced Materials due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 8/344, thus managing to position itself as a Q1 (Primer Cuartil), in the category Nanoscience & Nanotechnology. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations from Scopus Elsevier, it yields a value for the Field-Weighted Citation Impact from the Scopus agency: 3.97, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 5.59 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-05, the following number of citations:

  • WoS: 4
  • Scopus: 25
  • OpenCitations: 15
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 27.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 27 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 433.92.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 33 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/20.500.11797/imarina9283387
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Australia; China; United States of America.