{rfName}

Indexed in

License and use

Icono OpenAccess

Citations

3

Altmetrics

Analysis of institutional authors

Ferre, NataliaAuthorParada, EsterAuthorFeliu, AlbertAuthorEscribano, JoaquinCorresponding Author

Share

Publications
>
Review

Pharmacological interventions for preventing complications in patients with idiopathic hypercalciuria: A systematic review

Publicated to:Nefrologia. 42 (5): 506-518 - 2022-09-07 42(5), DOI: 10.1016/j.nefro.2021.04.007

Authors: Ferre N; Parada E; Balaguer A; Feliu A; Roqué-Figuls M; Franco JVA; Escribano J

Affiliations

Biomed Res Inst St Pau IIB St Pau, Iberoamer Cochrane Ctr, CIBER Epidemiol & Salud Publ CIBERESP, St Quinti 77-79, Barcelona 08041, Spain - Author
Hosp Univ Gen Catalunya, Dept Pediat, Pere Pons 1, Pere & Pons 1, Barcelona 08195, Spain - Author
Hosp Univ St Joan Reus, Dept Pediat, Avinguda Doctor Josep Laporte 2, Reus 43204, Spain - Author
Hosp Univ Tarragona Joan XXIII, Dept Pediat, Dr Mallafre Guasch 4, Tarragona 43005, Spain - Author
Inst Univ Hosp Italiano, Argentine Cochrane Ctr, Potosi 4265, Potosi 4265,C1199 CABA, Buenos Aires, Argentina - Author
Univ Int Catalunya, Carrer Immaculada 22, Barcelona 08017, Spain - Author
Univ Rovira & Virgili, Sch Med, Pediat Res Unit, Sant Llorenc 21, Reus 43201, Spain - Author
See more

Abstract

Objective: To assess the effects of pharmacological interventions in patients with idiopathic hypercalciuria.Methods: We performed a search of multiple databases, trial registries, grey literature and conference proceedings up to October 2019. We included randomized and quasi-randomized controlled trials that examined any pharmacological intervention for preventing complications of idiopathic hypercalciuria (given for at least four months and six of follow-up). The primary outcomes were stone-free patients, urinary symptoms and severe adverse events.Results: We included five RCTs (n = 446 patients, all adults, 4 in individuals with kidney stones and 1 in postmenopausal women with osteoporosis). Diuretics were likely to increase the number of stone-free patients (RR 1.61, 95% CI 1.33-1.96, moderate quality of evidence (QoE)); 274 more stone-free patients/1000 patients treated (95% CI: 148-432) and produced a slight decrease in the stone formation rate (mean difference -0.18, 95% CI -0.30 to -0.06, low QoE); 180 fewer stones/year/1000 patients treated (95% CI: 300 r to 60). No data on urinary symptoms were reported. The association between diuretic use and severe adverse events was uncertain (RR 5.00, 95% CI 0.60-41.88, very low QoE); 4 more severe adverse events/1000 patients treated (95% CI: 0 fewer to 39 more).Conclusions: The addition of diuretics to a normal or modified diet probably reduces the number of stone recurrences and may decrease the stone formation rate. It is uncertain whether diuretics increase the occurrence of severe adverse events. There were no studies investigating other outcomes or in children. (C) 2021 Sociedad Espanola de Nefrologia. Published by Elsevier Espana, S.L.U.

Keywords

AdultAlendronateBone-mineral densityChildChildrenCitrateDiuréticos, cálculos renalesDiureticsFemaleHipercaliuria idiopáticaHumansHypercalciuriaIdiopathic hypercalciuriaIndapamideKidney calculiKidney stonesMassOsteoporosisRecurrent nephrolithiasisRevisión sistemáticaRiskSystematic reviewUrine calciumUrolithiasis

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Nefrologia, and although the journal is classified in the quartile Q3 (Agencia WoS (JCR)), its regional focus and specialization in Urology & Nephrology, give it significant recognition in a specific niche of scientific knowledge at an international level.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.12, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-27, the following number of citations:

  • WoS: 1
  • Scopus: 1
  • Europe PMC: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-27:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 35.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 97 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.75.
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Additionally, the work has been submitted to a journal classified as Diamond in relation to this type of editorial policy.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/20.500.11797/imarina9287383

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Argentina.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Ferre Pallas, Natalia) and Last Author (Escribano Subías, Joaquín).

the author responsible for correspondence tasks has been Escribano Subías, Joaquín.