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Grant support

The ECLIPSES trial was supported by the Spanish government's official funding agency for biomedical research, ISCIII, through the Fondo de Investigacion para la para la Salud (FIS) andco-funded by the European Union (ERDF/ESF, "A way to make Europe"/"Investing in your future")(two FIS projects: PI12/02777, PI17/01754). The funding bodies played no part in the design of this study, the collection and interpretation of data, or decision to publish. A.D. is a Serra Hunter Fellow, Spain.

Analysis of institutional authors

Díaz-Torres, SandraAuthorDiaz-Lopez, AndresAuthorArija, VictoriaCorresponding Author

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February 26, 2024
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Effect of Prenatal Iron Supplementation Adapted to Hemoglobin Levels in Early Pregnancy on Fetal and Neonatal Growth-ECLIPSES Study

Publicated to:Nutrients. 16 (3): 437- - 2024-02-01 16(3), DOI: 10.3390/nu16030437

Authors: Diaz-Torres, Sandra; Diaz-Lopez, Andres; Arija, Victoria

Affiliations

Inst Invest Sanitaria Pere Virgili IISPV, Tarragona 43005, Spain - Author
Jordi Gol Primary Care Res Inst, Tarragona Reus Res Support Unit, Collaborat Grp Lifestyles Nutr & Tobacco CENIT, Reus 43202, Spain - Author
Univ Rovira & Virgili URV, Nutr & Mental Hlth NUTRISAM Res Grp, Reus 43204, Spain - Author

Abstract

In this randomized clinical trial, we evaluated the effects of prenatal iron supplementation adapted to pregnant women's initial hemoglobin (Hb) levels on fetal growth parameters until birth in women from the Mediterranean coast of northern Spain. All (n = 791) women were iron-supplemented during pregnancy according to Hb levels at the 12th gestational week: stratum 1 (Hb: 110-130 g/L) received 40 or 80 mg iron daily; stratum 2 (Hb > 130 g/L) received 40 or 20 mg iron daily. Fetal biometric and anthropometric measurements were evaluated in the three trimesters and at birth, respectively. In stratum 1, using 80 mg/d instead of 40 mg/d increased the risk of fetal head circumference > 90th percentile (OR = 2.49, p = 0.015) at the second trimester and fetal weight (OR = 2.36, p = 0.011) and femur length (OR = 2.50, p = 0.018) < 10th percentile at the third trimester. For stratum 2, using 40 mg/d instead of 20 mg/d increased the risk of fetal head circumference > 90th percentile (OR = 3.19, p = 0.039) at the third trimester. A higher risk of delivering an LGA baby (OR = 2.35, p = 0.015) for birthweight was also observed in stratum 1 women receiving 80 mg/d. It is crucial to adjust the prenatal iron supplementation to each pregnant woman's needs, i.e., adapted to their initial Hb levels, to achieve optimal fetal development, since excessive iron doses appear to adversely influence fetal growth.

Keywords

AnemiaBirth-weightDietary supplementsEclipses studyFemaleFetal biometricsFetal developmentHemoglobinsHumansInfant, newbornIronIron supplementationOutcomesOxidative stressPopulationPregnancyPrenatal carePrepregnancy overweightRiskStandardsTrialVitaminsWomen

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Nutrients due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 18/114, thus managing to position itself as a Q1 (Primer Cuartil), in the category Nutrition & Dietetics.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-16:

  • WoS: 5
  • Scopus: 3
  • Europe PMC: 2

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 61.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 75 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 18.25.
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).
  • The number of mentions in news outlets: 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/20.500.11797/imarina9363618

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Díaz Torres, Sandra) and Last Author (Arija Val, Maria Victoria).

the author responsible for correspondence tasks has been Arija Val, Maria Victoria.