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Grant support

The authors would like to acknowledge the participants and families who took the time to participate in the research. This work was supported by the Instituto de Salud Carlos III (grant numbers PI18/00514, PI21/00848, and PI21/00612) and co-funded by the European Union; the Generalitat de Catalunya (grant number SLT006/17/357); the IISPV-Cerca Program of the Generalitat de Catalunya; and co-funded by FEDER; the Catalan Agency of Research and Universities (AGAUR) (grant numbers 2017SGR-00444 and 2021SGR-01065); and the Universitat Rovira I Virgili-Marti Franques program (grant number PMF2021-IN000681 to Marti Llaurador-Coll).

Analysis of institutional authors

Llaurador-Coll, MartiAuthorSole, MontseAuthorVilella, ElisabetAuthorSanchez-Gistau, VanessaCorresponding Author
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Article

Sex differences in the association of overweight with cognitive performance in individuals with first-episode psychosis

Publicated to:Schizophrenia. 10 (1): 95- - 2024-10-23 10(1), DOI: 10.1038/s41537-024-00521-w

Authors: Llaurador-Coll, Marti; Cabezas, Angel; Algora, M Jose; Sole, Montse; Vilella, Elisabet; Sanchez-Gistau, Vanessa

Affiliations

Hosp Univ Inst Pere Mata HU IPM, Ctra Inst Pere Mata S-N, Reus 43206, Spain - Author
Inst Invest Sanitaria Pere Virgili IISPV CERCA, Ave Josep Laporte 2, Reus 43204, Spain - Author
Inst Salud Carlos III ISCIII, Ctr Invest Biomed Red Salud Mental CIBERSAM, Ave Monforte Lemos,3-5 Pabellon 11 Planta 0, Madrid 28029, Spain - Author
Univ Rovira & Virgili URV, Dept Med & Cirurgia, Mycol Unit, C St Llorenc 21, Reus 43201, Spain - Author

Abstract

Cognitive deficits and overweight are prominent challenges in the treatment of psychosis, which have a direct impact on patients' quality of life. We aim to determine whether there is an association of overweight with cognitive performance and whether there are sex differences in this association. We included 170 individuals with first-episode psychosis (FEP) (mean age 23.08 years, 32.9% females) attending an early intervention service who underwent clinical, biometric, and cognitive assessments by the MATRICS Consensus Cognitive Battery. A set of two-way analyses of covariance (ANCOVAs) were conducted for each cognitive test. Sex, overweight, and their interaction were included as factors. Nearly 34% of the participants were overweight without differences between males and females. The excess of weight did not exert any main effect on cognition; however, overweight females performed significantly worse than non-overweight females in processing speed, verbal learning and memory, reasoning and problem-solving, and global cognitive function, whereas in males, there were no differences. Our findings highlight that sex matters in the study of metabolic and cognitive factors in FEP to develop targeted interventions based on sex perspectives.

Keywords
1st episodeBody-mass indexConsensusDisordeHypertensionImpairmentMetaanalysisMetabolic syndromeObesitySchizophrenia

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Schizophrenia due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 95/279, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Psychiatry.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-04-29:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 7.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 7 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.5.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/20.500.11797/imarina9389467
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (LLAURADOR COLL, MARTÍ) and Last Author (Sánchez Gistau, Vanessa).

the author responsible for correspondence tasks has been Sánchez Gistau, Vanessa.