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The authors are grateful to the Uruguayan organizations PEDE-CIBA (Programa de Desarrollo de las Ciencias Basicas), ANII (Agencia Nacional de Investigacion e Innovacion) and CSIC (Programa de Apoyo a Grupos) for financial support.

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Macho, IsraelAuthor

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March 27, 2025
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Potentiometric and spectroscopic study of the interaction of 3d transition metal ions with inositol hexakisphosphate

Publicated to:Journal Of Molecular Structure. 1098 55-65 - 2015-10-15 1098(), DOI: 10.1016/j.molstruc.2015.05.034

Authors: Veiga, Nicolas; Macho, Israel; Gomez, Kerman; Gonzalez, Gabriel; Kremer, Carlos; Torres, Julia

Affiliations

Inst Catala Invest Quim, Tarragona 43007, Spain - Author
Univ Republica, Fac Quim, Dept Estrella Campos, Catedra Quim Inorgan, Montevideo, Uruguay - Author

Abstract

Among myo-inositol phosphates, the most abundant in nature is the myo-inositol hexakisphosphate, InsP(6). Although it is known to be vital to cell functioning, the biochemical research into its metabolism needs chemical and structural analysis of all the protonation, complexation and precipitation processes that it undergoes in the biological media. In view of its high negative charge at physiological level, our group has been leading a thorough research into the InsP(6) chemical and structural behavior in the presence of the alkali and alkaline earth metal ions essential for life. The aim of this article is to extend these studies, dealing with the chemical and structural features of the InsP(6) interaction with biologically relevant 3d transition metal ions (Fe(II), Fe(III), Mn(II), Co(II), Ni(II), Cu(II) and Zn(II)), in a non-interacting medium and under simulated physiological conditions. The metal-complex stability constants were determined by potentiometry, showing under ligand-excess conditions the formation of mononuclear species in different protonation states. Under metal ion excess, polymetallic species were detected for Fe(II), Fe(III), Zn(II) and Cu(II). Additionally, the P-31 NMR and UV vis spectroscopic studies provided interesting structural aspects of the strong metal ion-InsP(6) interaction. (C) 2015 Elsevier B.V. All rights reserved.

Keywords

3d transition metal cationsAqueous-solutionCalcium-phytateComplex-formationCytosolic/nuclear conditionsDivalent-cation interactionsInositol hexakisphosphateIron pooMyoinositol hexakisphosphateP-31 nmr of insp(6) complexesPhytic acidProtonation constantsSequestering abilitySolution chemistry of insp(6

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Molecular Structure, and although the journal is classified in the quartile Q3 (Agencia WoS (JCR)), its regional focus and specialization in Chemistry, Physical, give it significant recognition in a specific niche of scientific knowledge at an international level.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.39, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-09, the following number of citations:

  • WoS: 19

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-09:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 12 (PlumX).

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Uruguay.