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The PREDIMED-Plus trial was supported by the European Research Council (Advanced Research Grant 2013e2018, 340918) to M.A.M.-G., and the official funding agency for biomedical research of the Spanish government, ISCIII, through the Fondo de Investigacion para la Salud (FIS), which is co-funded by the European Regional Development Fund (five coordinated FIS projects led by J.S.-S. and J.Vid., including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926; PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332), the Especial Action Project entitled: Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus grant to J.S.-S., the Recercaixa grant to J.S.-S. (2013ACUP00194), grants from the Consejeria de Salud de la Junta de Andalucia (PI0458/2013, PS0358/2016, and PI0137/2018), a grant from the Generalitat Valenciana (PROMETEO/2017/017), a Fernando Tarongi Bauza PhD grant to Cristina Bouzas, a SEMERGEN grant, and funds from the European Regional Development Fund (CB06/03 and CB12/03). Nerea Becerra-Tomas was supported by a Juan de la Cierva Formacion postdoctoral fellowship (FJC2018e036016-I). Indira Paz Graniel receives a Grant from the Spanish Ministry of Education, Culture and Sports (FPU 17/01925). Anna Tresserra Rimbau was supported by a Juan de la Cierva Formacion postdoctoral fellowship (FJCI-2016-28694) from the Ministry of Economy, Industry and Competitivity. Laura Barrubes receives a Grant from the Spanish Ministry of Education, Culture and Sports (FPU 16/00165). Centro de Investigacion Biomedica en Red-Fisiopatologia de la Obesidad y Nutricion is an initiative of the Instituto de Salud Carlos III of Spain, which is financed by the European Regional Development Fund, "A way to make Europe"/"Investing in your future" (CB06/03 and CB12/03). It is supported by the official funding agency for biomedical research of the Spanish government, ISCIII, Spain.

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Fruit consumption and cardiometabolic risk in the PREDIMED-plus study: A cross-sectional analysis

Publicat a:Nutrition Metabolism And Cardiovascular Diseases. 31 (6): 1702-1713 - 2021-06-07 31(6), DOI: 10.1016/j.numecd.2021.02.007

Autors: Becerra-Tomas, Nerea; Paz-Graniel, Indira; Tresserra-Rimbau, Anna; Martinez-Gonzalez, Miguel A; Barrubes, Laura; Corella, Dolores; Munoz-Martinez, Julia; Romaguera, Dora; Vioque, Jesus; Alonso-Gomez, Angel M; Warnberg, Julia; Martinez, Jose A; Serra-Majem, Luis; Estruch, Ramon; Bernal-Lopez, Maria R; Lapetra, Jose; Pinto, Xavier; Tur, Josep A; Garcia-Rios, Antonio; Gallego, Blanca Riquelme; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Daimiel, Lidia; Velilla-Zancada, Sonsoles; Vidal, Josep; Vazquez, Clotilde; Ros, Emilio; Buil-Cosiales, Pilar; Babio, Nancy; Fernandez-Carrion, Rebeca; Perez-Vega, Karla A; Morey, Marga; Torres-Collado, Laura; Tojal-Sierra, Lucas; Perez-Lopez, Jessica; Abete, Itziar; Cabrera, Judith P; Casas, Rosa; Fernandez-Garcia, Jose C; Santos-Lozano, Jose M; Esteve-Luque, Virginia; Bouzas, Cristina; Fernandez-Lazaro, Cesar, I; Sorli, Jose, V; Freixer, Gala; Martin, Marian; Munoz, Montserrat G; Salaverria-Lete, Itziar; Toledo, Estefania; Castaner, Olga; Salas-Salvado, Jordi

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Background and aims: Total fruit consumption is important for cardiovascular disease prevention, but also the variety and form in which is consumed. The aim of the study was to assess the associations between total fruit, subgroups of fruits based on their color and fruit juices consumption with different cardiometabolic parameters.Methods and results: A total of 6633 elderly participants (aged 55-75 years) with metabolic syndrome from the PREDIMED-Plus study were included in this analysis. Fruit and fruit juice consumption was assessed using a food frequency questionnaire. Linear regression models were fitted to evaluate the association between exposure variables (total fruit, subgroups based on the color, and fruit juices) and different cardiometabolic risk factors. Individuals in the highest category of total fruit consumption (>3 servings/d) had lower waist circumference (WC) (13 = -1.04 cm; 95%CI:-1.81,-0.26), fasting glucose levels (13 =-2.41 mg/dL; 95%CI(-4.19,-0.63) and LDL-cholesterol (13 =-4.11 mg/dL; 95%CI:-6.93,-1.36), but, unexpectedly, higher systolic blood pressure (BP) (13 = 1.84 mmHg; 95%CI: 0.37, 3.30) and diastolic BP (13 = 1.69 mmHg; 95%CI:0.83, 2.56) when compared to those in the lowest category of consumption (<1 servings/d). Participants consuming >1 serving/day of total fruit juice had lower WC (13 = -0.92 cm; 95%CI:-1.56,-0.27) and glucose levels (13 =-1.59 mg/dL; 95%CI:-2.95,-0.23) than those consuming <1 serving/month. The associations with cardiometabolic risk factors differed according to the color of fruits.Conclusion: Fruit consumption is associated with several cardiometabolic risk factors in Mediterranean elders with metabolic syndrome. The associations regarding BP levels could be attributed, at least partially, to reverse causality bias inherent to the cross-sectional design of the study.(C)& nbsp;2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

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