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Funding for the present research was provided by ACC1O (TECCT11-1-0012). We gratefully acknowledge the assistance of the laboratory technicians Silvia Pijuan, Yaiza Tobajas, Iris Triguero, Gertruda Chomiciute and Beatriz Millan.

Analysis of institutional authors

Del Bas, J. M.AuthorCereto, A.AuthorRas, R.AuthorArola, L.Author
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Alterations in gut microbiota associated with a cafeteria diet and the physiological consequences in the host

Publicated to:International Journal Of Obesity. 42 (4): 746-754 - 2018-04-01 42(4), DOI: 10.1038/ijo.2017.284

Authors: del Bas, JM; Guirro, M; Boqué, N; Cereto, A; Ras, R; Crescenti, A; Caimari, A; Canela, N; Arola, L

Affiliations

EURECAT Technol Ctr Catalonia, Nutr & Hlth Res Grp, Reus, Spain - Author
EURECAT Technol Ctr Catalonia, Nutr & Hlth Unit, Reus, Spain - Author
Univ Rovira & Virgili, Dept Biochem & Biotechnol, Nutrigen Res Grp, Tarragona, Spain - Author
Univ Rovira & Virgili, EURECAT Technol Ctr Catalonia, GROM, Joint Unit,COS,Unique Sci & Tech Infrastruct ICTS, Reus, Spain - Author

Abstract

OBJECTIVE: Gut microbiota have been described as key factors in the pathophysiology of obesity and different components of metabolic syndrome (MetS). The cafeteria diet (CAF)-fed rat is a preclinical model that reproduces most of the alterations found in human MetS by simulating a palatable human unbalanced diet. Our objective was to assess the effects of CAF on gut microbiota and their associations with different components of MetS in Wistar rats. METHODS: Animals were fed a standard diet or CAF for 12 weeks. A partial least square-based methodology was used to reveal associations between gut microbiota, characterized by 165 ribosomal DNA gene sequencing, and biochemical, nutritional and physiological parameters. RESULTS: CAF feeding resulted in obesity, dyslipidemia, insulin resistance and hepatic steatosis. These changes were accompanied by a significant decrease in gut bacterial diversity, decreased Firmicutes and an increase in Actinobacteria and Proteobacteria abundances, which were concomitant with increased endotoxemia. Associations of different genera with the intake of lipids and carbohydrates were opposed from those associated with the intake of fiber. Changes in gut microbiota were also associated with the different physiological effects of CAF, mainly increased adiposity and altered levels of plasma leptin and glycerol, consistent with altered adipose tissue metabolism. Also hepatic lipid accretion was associated with changes in microbiota, highlighting the relevance of gut microbiota homeostasis in the adipose-liver axis. CONCLUSIONS: Overall, our results suggest that CAF feeding has a profound impact on the gut microbiome and, in turn, that these changes may be associated with important features of MetS.

Keywords
EndotoxemiaHigh-fat-dietIncreasesInduced obesityInflammationInsulin sensitivityLiver-diseaseMetabolic syndromeRichnessSignature

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal International Journal Of Obesity due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2018, it was in position 12/87, thus managing to position itself as a Q1 (Primer Cuartil), in the category Nutrition & Dietetics.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.04. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 1.1 (source consulted: FECYT Feb 2024)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-23, the following number of citations:

  • WoS: 31
  • Scopus: 33
  • Europe PMC: 3
  • Google Scholar: 38
  • OpenCitations: 29
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-23:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 118.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 117 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 21.13.
  • The number of mentions on the social network X (formerly Twitter): 14 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Del Bas Prior, José María) and Last Author (Arola Ferrer, Luis Maria).