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Analysis of institutional authors

Martínez Micaelo, Nieves BeatrizAuthorTerra, XimenaAuthorArdevol, AnaAuthorPinent, MontserratAuthorBlay, MayteCorresponding Author

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May 6, 2021
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Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet

Publicated to:Disease Models & Mechanisms. 9 (10): 1231-1239 - 2016-10-01 9(10), DOI: 10.1242/dmm.025528

Authors: Martinez-Micaelo, Neus; Gonzalez-Abuin, Noemi; Terra, Ximena; Ardevol, Ana; Pinent, Montserrat; Petretto, Enrico; Behmoaras, Jacques; Blay, Mayte

Affiliations

Duke NUS Grad Med Sch Singapore, 8 Coll Rd, Singapore 169857, Singapore - Author
Imperial Coll London, Ctr Complement & Inflammat Res, Du Cane Rd, London W12 0NN, England - Author
Imperial Coll London, Hammersmith Hosp, MRC Clin Sci Ctr, Du Cane Rd, London W12 0NN, England - Author
Univ Rovira & Virgili, Dept Biochem & Biotechnol, Mobiofood Res Grp, Tarragona 43003, Spain - Author

Abstract

Obesity has reached pandemic levels worldwide. The current models of diet-induced obesity in rodents use predominantly high-fat based diets that do not take into account the consumption of variety of highly palatable, energy-dense foods that are prevalent in Western society. We and others have shown that the cafeteria (CAF) diet is a robust and reproducible model of human metabolic syndrome with tissue inflammation in the rat. We have previously shown that inbred rat strains such as Wistar Kyoto (WKY) and Lewis (LEW) show different susceptibilities to CAF diets with distinct metabolic and morphometric profiles. Here, we show a difference in plasma MCP-1 levels and investigate the effect of the CAF diet on peripheral blood monocyte transcriptome, as powerful stress-sensing immune cells, in WKY and LEW rats. We found that 75.5% of the differentially expressed transcripts under the CAF diet were upregulated in WKY rats and were functionally related to the activation of the immune response. Using a gene co-expression network constructed from the genes differentially expressed between CAF diet-fed LEW and WKY rats, we identified acyl-CoA synthetase short-chain family member 2 (Acss2) as a hub gene for a nutrient-sensing cluster of transcripts in monocytes. The Acss2 genomic region is significantly enriched for previously established metabolism quantitative trait loci in the rat. Notably, monocyte expression levels of Acss2 significantly correlated with plasma glucose, triglyceride, leptin and non-esterified fatty acid (NEFA) levels as well as morphometric measurements such as body weight and the total fat following feeding with the CAF diet in the rat. These results show the importance of the genetic background in nutritional genomics and identify inbred rat strains as potential models for CAF-diet-induced obesity.© 2016. Published by The Company of Biologists Ltd.

Keywords

cafeteria dietinbred ratslewmonocyte transcriptomeCafeteria dietInbred ratsLewMonocyte transcriptomeWky

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Disease Models & Mechanisms due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2016, it was in position 10/79, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pathology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.36, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-04, the following number of citations:

  • WoS: 11
  • Scopus: 11
  • Europe PMC: 9
  • Google Scholar: 14

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-04:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 34.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 34 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.75.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/20.500.11797/imarina5129992

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Singapore; United Kingdom.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Martínez Micaelo, Nieves Beatriz) and Last Author (Blay Olivé, Maria Teresa).

the author responsible for correspondence tasks has been Blay Olivé, Maria Teresa.