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Analysis of institutional authors

Martinez MAuthorBlanco JCorresponding AuthorRovira JAuthorKumar VAuthorDomingo JlAuthorSchuhmacher MAuthor

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April 10, 2020
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Bisphenol A analogues (BPS and BPF) present a greater obesogenic capacity in 3T3-L1 cell line

Publicated to:Food And Chemical Toxicology. 140 (111298): 111298- - 2020-06-01 140(111298), DOI: 10.1016/j.fct.2020.111298

Authors: Martinez, M A; Blanco, J; Rovira, J; Kumara, V; Domingo, J L; Schuhmacher, M

Affiliations

Institut d'Investigació Sanitària Pere Virgili - Author
Univ Rovira & Virgili, Dept Engn Quim, Environm Engn Lab, Ave Paisos Catalans 26, Tarragona 43007, Catalonia, Spain - Author
Univ Rovira & Virgili, IISPV, Sch Med, Lab Toxicol & Environm Hlth, St Llorenc 21, Reus 43201, Catalonia, Spain - Author
Univ Rovira & Virgili, Res Neurobehav & Hlth NEUROLAB, Tarragona, Spain - Author
Universitat Rovira i Virgili - Author
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Abstract

© 2020 Elsevier Ltd This study was aimed at comparing the toxicity effects on cell viability and the obesogenic activity of Bisphenol A (BPA) and its analogues, Bisphenol S (BPS) and Bisphenol F (BPF), by in vitro assays with a preadipocytic 3T3-L1 cell line. To compare the toxic potential and select the concentrations of each chemical not showing a decrease in cell viability, MTT assay was performed. The cell phenotype was determined in differentiated 3T3-L1 adipocytes by red oil O staining. To determine the expression levels of the different adipogenic proteins the Western Blot test was performed. The results from MTT assay showed a greater toxic effect of BPA - at equal and even lower concentrations-than its analogues. However, BPS followed by BPF showed a greater neutral lipid storage capacity than BPA, which was reflected in the increase of the protein expression of CCAAT/enhancer binding protein α (C/EBPα), peroxisome proliferator-activated receptor gamma γ (PPARγ) and acid-binding protein 4 (FABP4). In summary, these BPA analogues -especially BPS- present a greater endocrine potential activity than BPA.

Keywords

adipogenesisanaloguesbisphenol a (bpa)cell viability3t3-l1 cellsAdipogenesisAnaloguesAnimalsBenzhydryl compoundsBis(4-hydroxyphenyl)sulfoneBisphenol a (bpa)Bisphenol fCcaat-enhancer-binding protein-alphaCell differentiationCell viabilityChildrenCleanupDietaryEndocrine disruptorsEndocrine potential activityExposureFabp4 protein, mouseFatty acid-binding proteinsHuman-milkLipid metabolismMiceObesityPhenolsPpar gammaPreadipocytesPregnant-womenSulfonesUp-regulation

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Food And Chemical Toxicology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position 9/93, thus managing to position itself as a Q1 (Primer Cuartil), in the category Toxicology. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2.88. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 2.49 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 10.84 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-18, the following number of citations:

  • WoS: 51
  • Scopus: 56
  • Europe PMC: 17
  • Google Scholar: 63

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-18:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 71.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 77 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 21.35.
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).
  • The number of mentions in news outlets: 2 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Martínez Rodríguez, María Ángeles) and Last Author (Schuhmacher Ansuategui, Marta).

the author responsible for correspondence tasks has been Blanco Pérez, Jordi.