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This research was funded by Lo.Li. Pharma srl.

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Maymo-Masip, ElsaAuthor
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Article

D-Chiro-Inositol and Myo-Inositol Induce WAT/BAT Trans-Differentiation in Two Different Human Adipocyte Models (SGBS and LiSa-2)

Publicated to:International Journal Of Molecular Sciences. 24 (8): 7421- - 2023-04-01 24(8), DOI: 10.3390/ijms24087421

Authors: Monastra, Giovanni; Gambioli, Riccardo; Unfer, Vittorio; Forte, Gianpiero; Maymo-Masip, Elsa; Comitato, Raffaella

Affiliations

Council Agr Res & Econ, Res Ctr Food & Nutr, I-00178 Rome, Italy - Author
Experts Grp Inositols Basic & Clin Res EGOI, I-00161 Rome, Italy - Author
Inst Invest Sanitaria Pere Virgili IISPV, Tarragona 43003, Spain - Author
Inst Salud Carlos III, CIBER Diabet & Enfermedades Metaboil Asociadas CIB, Madrid 28029, Spain - Author
Lo Li Pharm, R&D Dept, I-00156 Rome, Italy - Author
Syst Biol Grp Lab, I-00161 Rome, Italy - Author
UniCamillus St Camillus Int Univ Hlth Sci, I-00131 Rome, Italy - Author
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Abstract

White adipose tissue/brown adipose tissue trans-differentiation is one of the main study targets for therapies against obesity and metabolic diseases. In recent years, numerous molecules able to induce such trans-differentiation have been identified; however, their effect in obesity therapies has not been as expected. In the present study, we investigated whether myo-inositol and its stereoisomer D-chiro-inositol could be involved in the browning of white adipose tissue. Our preliminary results clearly indicate that both, at 60 mu M concentration, induce the upregulation of uncoupling protein 1 mRNA expression, the main brown adipose tissue marker, and increase mitochondrial copy number as well as oxygen consumption ratio. These changes demonstrate an activation of cell metabolism. Therefore, our results show that human differentiated adipocytes (SGBS and LiSa-2), assume the features typical of brown adipose tissue after both treatments. Furthermore, in the cell lines examined, we proved that D-chiro-inositol and myo-Inositol induce an increase in the expression of estrogen receptor mRNAs, suggesting a possible modulation by these isomers. We also found an increase in the mRNA of peroxisome proliferator-activated receptor gamma, a very important target in lipid metabolism and metabolic diseases. Our results open new opportunities for the use of inositols in therapeutic strategies to counteract obesity and its metabolic complications.

Keywords
AdipocytesAdipogenesisAdipose tissue, brownAdipose tissue, whiteBrown adipose tissueBrown adipose-tissueCell transdifferentiationCellsD-chiro-inositolEstrogen receptorEstrogen-receptor-alphaExpressionHigh-capacityHumansInositolLipid-metabolismMyo-inositolObesityPpar-gammaPpar-γRna, messengerThermogenesisTrans-differentiationUcp-1WhiteWhite adipose tissue

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal International Journal Of Molecular Sciences due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 66/313, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry & Molecular Biology.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.06. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 1.08 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 2.65 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-23, the following number of citations:

  • WoS: 7
  • Scopus: 8
  • Europe PMC: 4
  • OpenCitations: 5
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-23:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 11.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 11 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.5.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Italy.