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Analysis of institutional authors

Cortés-Espinar AjAuthorIbarz-Blanch NAuthorSoliz-Rueda JrAuthorBravo FiAuthorCalvo EAuthorávila-Román JCorresponding AuthorMulero MCorresponding Author

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September 4, 2023
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Rhythm and ROS: Hepatic Chronotherapeutic Features of Grape Seed Proanthocyanidin Extract Treatment in Cafeteria Diet-Fed Rats

Publicated to:Antioxidants. 12 (8): 1606- - 2023-08-01 12(8), DOI: 10.3390/antiox12081606

Authors: Cortes-Espinar, Antonio J; Ibarz-Blanch, Nestor; Soliz-Rueda, Jorge R; Bonafos, Beatrice; Feillet-Coudray, Christine; Casas, Francois; Bravo, Francisca Isabel; Calvo, Enrique; Avila-Roman, Javier; Mulero, Miquel

Affiliations

Inst Invest Sanitaria Pere Virgili, Nutrigen Res Grp, Tarragona 43007, Spain - Author
Institut d'Investigació Sanitària Pere Virgili , Universitat Rovira i Virgili - Author
Univ Montpellier, DMEM, EMN, UMR 866,INRAe, F-34090 Montpellier, France - Author
Univ Rovira i Virgili, Dept Biochem & Biotechnol, Nutrigen Res Grp, Tarragona 43007, Spain - Author
Univ Seville, Dept Pharmacol, Mol & Appl Pharmacol Grp FARMOLAP, Seville 41012, Spain - Author
Universidad de Sevilla - Author
Université de Montpellier - Author
Université de Montpellier , Institut d'Investigació Sanitària Pere Virgili , Universitat Rovira i Virgili - Author
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Abstract

Polyphenols play a key role in the modulation of circadian rhythms, while the cafeteria diet (CAF) is able to perturb the hepatic biological rhythm and induce important ROS production. Consequently, we aimed to elucidate whether grape seed proanthocyanidin extract (GSPE) administration recovers the CAF-induced hepatic antioxidant (AOX) misalignment and characterize the chronotherapeutic properties of GSPE. For this purpose, Fischer 344 rats were fed a standard diet (STD) or a CAF and concomitantly treated with GSPE at two time-points (ZT0 vs. ZT12). Animals were euthanized every 6 h and the diurnal rhythms of hepatic ROS-related biomarkers, hepatic metabolites, and AOX gene expression were examined. Interestingly, GSPE treatment was able to recover the diurnal rhythm lost due to the CAF. Moreover, GSPE treatment also increased the acrophase of Sod1, as well as bringing the peak closer to that of the STD group. GSPE also corrected some hepatic metabolites altered by the CAF. Importantly, the differences observed at ZT0 vs. ZT12 due to the time of GSPE administration highlight a chronotherapeutic profile on the proanthocyanin effect. Finally, GSPE could also reduce diet-induced hepatic oxidative stress not only by its ROS-scavenging properties but also by retraining the circadian rhythm of AOX enzymes.

Keywords

antioxidantcafeteria dietchronotherapycircadian rhythmscircadian-clockdiurnal rhythmsgene-expressionglutathionegspeinflammationlivermetabolic syndromemodulateobesityphenolic compoundsproanthocyanidinstranslationzeitgeberCafeteria dietChronotherapyCircadian rhythmsDiurnal rhythmsGspeLiverOxidative stressPhenolic compoundsProanthocyanidinsZeitgeber

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Antioxidants due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 8/72, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Medicinal. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.62, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-05, the following number of citations:

  • WoS: 3
  • Scopus: 4
  • Europe PMC: 2

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 21.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 21 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.5.
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/20.500.11797/imarina9329067

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: France.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Cortés Espinar, Antonio Jesús) and Last Author (Mulero Abellán, Miguel).

the authors responsible for correspondence tasks have been Ávila Román, Francisco Javier and Mulero Abellán, Miguel.