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Grant support

The ECLIPSES trial was supported by the financially by the Spanish government's official funding agency for biomedical research, Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS) (Nos. PI12/ 02777 and PI17/01754) and co-funded by the European Union ERDF/ESF, "A way to make Europe"/"Investing in your future". These funding bodies played no part in designing the study, collecting and interpreting the data, or deciding to publish. A.D. is a Serra Hunter Fellow, Spain.

Analysis of institutional authors

Motevalizadeh EAuthorDíaz-López AAuthorMartin FAuthorBasora JAuthorArija VAuthor

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Article

Association of Parity With Insulin Resistance Early in Pregnant Women: ECLIPSES Study

Publicated to:Journal Of Clinical Endocrinology & Metabolism. 109 (3): 730-739 - 2024-01-01 109(3), DOI: 10.1210/clinem/dgad594

Authors: Motevalizadeh, Ehsan; Diaz-Lopez, Andres; Martin, Francisco; Basora, Josep; Arija, Victoria

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Abstract

Little is known about whether parity is associated with elevated early-pregnancy IR, or whether overweight/obesity contributes to increasing the possible effect.We determined the associations between parity and glucose metabolism parameters in the first trimester of pregnancy in a Mediterranean pregnant population, and whether these associations are impacted by overweight/obesity.Cross-sectional study of 264 healthy pregnant women from the ECLIPSES study who were recruited at 12 weeks of gestation. At baseline, details on socio-economic status, obstetric history (including parity, i.e., number of births), lifestyle factors, anthropometry, and blood samples were collected. Fasting serum glucose, insulin, and HOMA-IR index were assessed in the first trimester. Elevated IR was defined as the upper HOMA-IR tertile (≥1.58). Multivariable linear regression and Cox regression model with constant time were performed.Parity ranged from 0-4. After multivariable adjustment, the insulin levels (β (% change): 20.92, 95%CI: 4.08, 37.71) and HOMA-IR index (β (% change): 19.72, 95%CI: 2.43, 40.49) were positively associated with parity. Additionally, multiparous women, as compared to nulliparous, were more likely to have higher HOMA-IR levels (primiparous (one birth), β (% change): 16.88, 95%CI: -1.00, 37.99; multiparous (≥2 two births), β (% change): 32.18, 95%CI: 3.56, 68.71), and an increased relative risk (RR) of an elevated IR (primiparous (one birth), RR: 1.55, 95%CI: 1.03, 2.36; multiparous (≥2 two births), RR: 1.72, 95%CI: 1.05, 2.83). The combination of multiparity and overweight/obesity conferred a 3.04-fold increase in the RR of elevated IR, which increased proportionally to the number of parities.This study demonstrates that parity may have a negative impact on early-pregnancy IR and that maternal overweight/obesity appears to further aggravate this relationship.© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Keywords

ageeclipsesglucosehoma-irinsulin resistancemothermultiparousobesitypregnancyriskvalidationweightBlood glucoseBody mass indexCross-sectional studiesEclipsesFemaleGestational diabetes-mellitusHumansInsulinInsulin resistanceMultiparousObesityOverweightParityPregnancyPregnant peoplePregnant women

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Clinical Endocrinology & Metabolism due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 30/186, thus managing to position itself as a Q1 (Primer Cuartil), in the category Endocrinology & Metabolism.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.05, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-08, the following number of citations:

  • WoS: 1
  • Scopus: 1
  • OpenCitations: 2

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-08:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 13.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 13 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 4.1.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 7 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Motevalizadeh, Ehsan) and Last Author (Arija Val, Maria Victoria).