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Funding sources This research was financially supported by the Agency for Business Competitiveness of the Government of Catalonia (ACCIO/TECCT11-1-/TECCT11-1-0012) and by Comunidad de Madrid (S2022/BMD-7403 RENIM-CM) .

Analysis of institutional authors

Baudin, JulioAuthorArola LAuthorArola, LluisCorresponding Author

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Article

A cocktail of histidine, carnosine, cysteine and serine reduces adiposity and improves metabolic health and adipose tissue immunometabolic function in ovariectomized rats

Publicated to:Biomedicine & Pharmacotherapy. 179 117326- - 2024-10-01 179(), DOI: 10.1016/j.biopha.2024.117326

Authors: Baudin, Julio; Hernandez-Baixauli, Julia; Romero-Gimenez, Jordi; Yang, Hong; Mulero, Francisca; Puiggros, Francesc; Mardinoglu, Adil; Arola, Lluis; Caimari, Antoni

Affiliations

Eurecat, Ctr Tecnol Catalunya, Biotechnol Area, Reus 43204, Spain - Author
Eurecat, Ctr Tecnol Catalunya, Technol Unit Nutr & Hlth, Reus 43204, Spain - Author
Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London, England - Author
KTH Royal Inst Technol, Sci Life Lab, SE-17165 Stockholm, Sweden - Author
Spanish Natl Canc Res Ctr CNIO, Mol Imaging Unit, Madrid, Spain - Author
Univ Autonoma Barcelona, Vall dHebron Inst Recerca, Lab Metab & Obes, Barcelona, Spain - Author
Univ Rovira i Virgili, Dept Biochem & Biotechnol, Nutrigenom Res Grp, Tarragona 43007, Spain - Author
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Abstract

Many women have sought alternative therapies to address menopause. Recently, a multi-ingredient supplement (MIS) containing L-histidine, L-carnosine, L-serine, and L-cysteine has been shown to be effective at ameliorating hepatic steatosis (HS) in ovariectomized (OVX) rats, a postmenopausal oestrogen deficiency model. Considering that HS frequently accompanies obesity, which often occurs during menopause, we aimed to investigate the effects of this MIS for 8 weeks in OVX rats. Twenty OVX rats were orally supplemented with either MIS (OVX-MIS) or vehicle (OVX). Ten OVX rats received vehicle orally along with subcutaneous injections of 17 beta-oestradiol (OVX-E2), whereas 10 rats underwent a sham operation and received oral and injected vehicles (control group). MIS consumption partly counteracted the fat mass accretion observed in OVX animals, leading to decreased total fat mass, adiposity index and retroperitoneal white adipose tissue (RWAT) adipocyte hypertrophy. OVX-MIS rats also displayed increased lean mass and lean/fat ratio, suggesting a healthier body composition, similar to the results reported for OVX-E2 animals. MIS consumption decreased the circulating levels of the proinflammatory marker CRP, the total cholesterol-to-HDL-cholesterol ratio and the leptin-to-adiponectin ratio, a biomarker of diabetes risk and metabolic syndrome. RWAT transcriptomics indicated that MIS favourably regulated genes involved in adipocyte structure and morphology, cell fate determination and differentiation, glucose/insulin homeostasis, inflammation, response to stress and oxidative phosphorylation, which may be mechanisms underlying the beneficial effects described for OVX-MIS rats. Our results pave the way for using this MIS formulation to improve the body composition and immunometabolic health of menopausal women.

Keywords

Body-compositionCarnosineCell functionComplementary and alternative therapieComplementary and alternative therapiesCysteineElevated plus-mazeExpressionFood-intakeHistidineImmunometabolic healthInflammationInsulin-resistanceMenopauseNf-kappa-bNutraceuticalsObesityOxidative stressSerineSupplementatio

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Biomedicine & Pharmacotherapy due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 22/189, thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine, Research & Experimental.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-06-20:

  • WoS: 1
  • Scopus: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-20:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 25 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/20.500.11797/imarina9380939

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Sweden; United Kingdom.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Baudin Luque, Julio Carlos) and Last Author (Caimari, Antoni).

the authors responsible for correspondence tasks have been Arola Fernández, Lluís and Caimari, Antoni.