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This work was supported by a project grant from the Fundacion Francisco Soria Melguizo. The project also received support from the Community of Madrid and the European Union, through the European Regional Development Fund (ERDF)-REACT-EU resources of the Madrid Operational Program 2014-2020, in the action line of R + D + i projects in response to COVID-19, FACINGLCOVID-CM. The PREDIMED-Plus trial was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS), which is co-funded by the European Regional Development Fund. This study has been funded by Instituto de Salud Carlos III (ISCIII) through six coordinated FIS projects leaded by JS-S and JVi, including the follow-ing projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158; the Especial Action Project entitled: "Implement-acion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus grant to JS-S" and co-funded by the European Union. It is also supported by the European Research Council (Advanced Research Grant 2014-2019; agreement #340918) granted to M & Aacute;M-G; the Recercaixa (number 2013ACUP00194) grant to JS-S; grants from the Consejeria de Salud de la Junta de Andalucia (PI0458/2013, PS0358/2016, PI0137/2018); the PROMETEO/2017/017, PROMETEO 21/2021 grants from the Generalitat Valenciana; and the SEMERGEN grant. S.G.S is a recipient of the Maria Zambrano Fellowship with funding support from the Ministry of Universities and the Recovery, Transformation and Resilience Plan, Spain. The Fellowship is "Funded by the European Union - NextGenerationEU". S.K.N. is supported by a postdoctoral fellowship from the Canadian Institutes of Health Research (CIHR, MFE-171207). JS-S was partially supported by ICREA under the ICREA Academia program. We thank CERCA Programme/Generalitat de Catalunya for institutional support. The funders had no role in study design, data collection and analysis, the decision to publish, or the preparation of the manuscript.

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Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort

Publicado en:Bmc Medicine. 21 (1): 390-390 - 2023-10-13 21(1), DOI: 10.1186/s12916-023-03079-z

Autores: Shyam, Sangeetha; Garcia-Gavilan, Jesus Francisco; Paz-Graniel, Indira; Gaforio, Jose J; Gaforio, Jose J; Martinez-Gonzalez, Miguel angel; Corella, Dolores; Martinez, J Alfredo; Martinez, J Alfredo; Alonso-Gomez, angel M; Alonso-Gomez, angel M; Waernberg, Julia; Vioque, Jesus; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J; Tinahones, Francisco J; Lapetra, Jose; Serra-Majem, J Luis; Serra-Majem, J Luis; Bueno-Cavanillas, Aurora; Tur, Josep A; Tur, Josep A; Sanchez, Vicente Martin; Pinto, Xavier; Matia-Martin, Pilar; Vidal, Josep; Vazquez, Clotilde; Daimiel, Lidia; Ros, Emilio; Fernandez-Aranda, Fernando; Nishi, Stephanie K; Nishi, Stephanie K; Garcia-Regata, Oscar; Toledo, Estefania; Asensio, Eva M; Asensio, Eva M; Castaner, Olga; Garcia-Rios, Antonio; Torres-Collado, Laura; Gomez-Gracia, Enrique; Zulet, M Angeles; Zulet, M Angeles; Ruiz, Nuria Goni; Casas, Rosa; Cano-Ibanez, Naomi; Tojal-Sierra, Lucas; Gomez-Perez, A M; Gomez-Perez, A M; Sorli, Jose V; Sorli, Jose V; Cinza-Sanjurjo, Sergio; Martin-Pelaez, Sandra; Pena-Orihuela, Patricia J; Pena-Orihuela, Patricia J; Oncina-Canovas, Alejandro; Perez-Araluce, Rafael; Zomeno, Maria Dolores; Chaplin, Alice; Delgado-Rodriguez, Miguel; Babio, Nancy; Fito, Montserrat; Salas-Salvado, Jordi

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Resumen

Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk.This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring.At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk.In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19.This study is registered at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870 ).© 2023. BioMed Central Ltd., part of Springer Nature.

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