Indexat a

Llicència i ús

Citacions

Cited 2 times in

Cited 3 times in

Cited 2 times in

Altmetrics

Grant support

This work was supported by a project grant from the Fundacion Francisco Soria Melguizo. The project also received support from the Community of Madrid and the European Union, through the European Regional Development Fund (ERDF)-REACT-EU resources of the Madrid Operational Program 2014-2020, in the action line of R + D + i projects in response to COVID-19, FACINGLCOVID-CM. The PREDIMED-Plus trial was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS), which is co-funded by the European Regional Development Fund. This study has been funded by Instituto de Salud Carlos III (ISCIII) through six coordinated FIS projects leaded by JS-S and JVi, including the follow-ing projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158; the Especial Action Project entitled: "Implement-acion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus grant to JS-S" and co-funded by the European Union. It is also supported by the European Research Council (Advanced Research Grant 2014-2019; agreement #340918) granted to M & Aacute;M-G; the Recercaixa (number 2013ACUP00194) grant to JS-S; grants from the Consejeria de Salud de la Junta de Andalucia (PI0458/2013, PS0358/2016, PI0137/2018); the PROMETEO/2017/017, PROMETEO 21/2021 grants from the Generalitat Valenciana; and the SEMERGEN grant. S.G.S is a recipient of the Maria Zambrano Fellowship with funding support from the Ministry of Universities and the Recovery, Transformation and Resilience Plan, Spain. The Fellowship is "Funded by the European Union - NextGenerationEU". S.K.N. is supported by a postdoctoral fellowship from the Canadian Institutes of Health Research (CIHR, MFE-171207). JS-S was partially supported by ICREA under the ICREA Academia program. We thank CERCA Programme/Generalitat de Catalunya for institutional support. The funders had no role in study design, data collection and analysis, the decision to publish, or the preparation of the manuscript.

Anàlisi d'autories institucional

Compartir

Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort

Publicat a:Bmc Medicine. 21 (1): 390-390 - 2023-10-13 21(1), DOI: 10.1186/s12916-023-03079-z

Autors: Shyam, Sangeetha; Garcia-Gavilan, Jesus Francisco; Paz-Graniel, Indira; Gaforio, Jose J; Gaforio, Jose J; Martinez-Gonzalez, Miguel angel; Corella, Dolores; Martinez, J Alfredo; Martinez, J Alfredo; Alonso-Gomez, angel M; Alonso-Gomez, angel M; Waernberg, Julia; Vioque, Jesus; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J; Tinahones, Francisco J; Lapetra, Jose; Serra-Majem, J Luis; Serra-Majem, J Luis; Bueno-Cavanillas, Aurora; Tur, Josep A; Tur, Josep A; Sanchez, Vicente Martin; Pinto, Xavier; Matia-Martin, Pilar; Vidal, Josep; Vazquez, Clotilde; Daimiel, Lidia; Ros, Emilio; Fernandez-Aranda, Fernando; Nishi, Stephanie K; Nishi, Stephanie K; Garcia-Regata, Oscar; Toledo, Estefania; Asensio, Eva M; Asensio, Eva M; Castaner, Olga; Garcia-Rios, Antonio; Torres-Collado, Laura; Gomez-Gracia, Enrique; Zulet, M Angeles; Zulet, M Angeles; Ruiz, Nuria Goni; Casas, Rosa; Cano-Ibanez, Naomi; Tojal-Sierra, Lucas; Gomez-Perez, A M; Gomez-Perez, A M; Sorli, Jose V; Sorli, Jose V; Cinza-Sanjurjo, Sergio; Martin-Pelaez, Sandra; Pena-Orihuela, Patricia J; Pena-Orihuela, Patricia J; Oncina-Canovas, Alejandro; Perez-Araluce, Rafael; Zomeno, Maria Dolores; Chaplin, Alice; Delgado-Rodriguez, Miguel; Babio, Nancy; Fito, Montserrat; Salas-Salvado, Jordi

Afiliacions

Resum

Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk.This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring.At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk.In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19.This study is registered at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870 ).© 2023. BioMed Central Ltd., part of Springer Nature.

Paraules clau